Continuously monitor vital signs during sedation and recovery period if coadministered. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Monitor Closely (1)triprolidine and doxepin both increase sedation. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results. Use Caution/Monitor.Minor (1)doxepin increases levels of atropine IV/IM by unknown mechanism. Serious - Use Alternative (1)linezolid and doxepin both increase serotonin levels. Modify Therapy/Monitor Closely. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug.paroxetine and doxepin both increase serotonin levels. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Assess need to reduce dose of CYP2D6-metabolized drug. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. Either increases toxicity of the other by serotonin levels. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Use Caution/Monitor.doxepin increases effects of epinephrine racemic by unknown mechanism. Selected from data included with permission and copyrighted by First Databank, Inc. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. almotriptan and doxepin both increase serotonin levels. Drug information provided by: IBM Micromedex. Effect of interaction is not clear, use caution. Use Caution/Monitor.doxepin increases levels of glycopyrrolate by unknown mechanism. Minor/Significance Unknown. Monitor Closely (1)itraconazole and doxepin both increase QTc interval. Monitor Closely (2)cenobamate, doxepin. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)fluoxetine and doxepin both increase serotonin levels. Contraindicated. Limit dosages and durations to the minimum required. Minor/Significance Unknown. Contraindicated. selinexor, doxepin. Minor/Significance Unknown. Minor (1)doxepin increases effects of rosiglitazone by pharmacodynamic synergism. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Modify Therapy/Monitor Closely. duloxetine and doxepin both increase serotonin levels. valbenazine and doxepin both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. doxepin and amisulpride both increase QTc interval. Avoid or Use Alternate Drug.Minor (2)doxepin, chlorpromazine. Avoid or Use Alternate Drug.amitriptyline and doxepin both increase serotonin levels. Minor/Significance Unknown. Use Caution/Monitor. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. gabapentin enacarbil, doxepin. Other (see comment). Avoid or Use Alternate Drug. butalbital and doxepin both increase sedation. propofol, doxepin. Minor/Significance Unknown. Migraines and gastrointestinal problems: Is there a link? Use Caution/Monitor. sertraline will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. eCollection 2022 Sep. Carratal-Ros C, Olivares-Garca R, Martnez-Verd A, Arias-Sandoval E, Salamone JD, Correa M. Psychopharmacology (Berl). Use Caution/Monitor. Minor (1)conjugated estrogens, doxepin. Coadministration may potentiate the CNS-depressant effects of each drug. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate increases effects of doxepin by unknown mechanism. Information last revised January 2023. Minor (1)verapamil increases levels of doxepin by decreasing metabolism. Risk of arrhythmias or hypotension. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor. Often, these people do not remember these events. Seasonal affective disorder treatment: Choosing a light box, Selective serotonin reuptake inhibitors (SSRIs), Serotonin and norepinephrine reuptake inhibitors (SNRIs), Staying active with hidradenitis suppurativa, Treating hidradenitis suppurativa: Explore your options, Treating hidradenitis suppurativa with antibiotics and hormones. Modify Therapy/Monitor Closely. Monitor Closely (2)stiripentol, doxepin. Avoid or Use Alternate Drug. Contraindicated. Monitor Closely (1)degarelix and doxepin both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, arformoterol. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. doxepin decreases effects of clonidine by Other (see comment). doxepin increases and dopexamine decreases sedation. Pamelor (prescribing information). doxepin and mifepristone both increase QTc interval. Modify Therapy/Monitor Closely. Use Caution/Monitor. Avoid or Use Alternate Drug. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). Other (see comment). Mayo Clinic does not endorse companies or products. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)nilotinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)granisetron, doxepin. Babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop withdrawal symptoms such as feeding/breathing difficulties, seizures, muscle stiffness, or constant crying. For this medicine, the following should be considered: Allergies Monitor Closely (1)loxapine inhaled and doxepin both increase sedation. Use Caution/Monitor. Monitor Closely (2)doxepin, lisdexamfetamine. doxepin: Sinequan, Zonalon, Silenor: . SIDE EFFECTS: Drowsiness or nausea may occur. doxepin and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. Consult your doctor for more details.As you get older, your sleep pattern may naturally change and your sleep may be interrupted several times during the night. Minor/Significance Unknown. Avoid or Use Alternate Drug. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and buprenorphine both increase QTc interval. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. Minor/Significance Unknown. Serious - Use Alternative (1)doxepin and vilanterol/fluticasone furoate inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Serious - Use Alternative (2)citalopram and doxepin both increase serotonin levels. Minor/Significance Unknown. Use Caution/Monitor. doxepin and fluconazole both increase QTc interval. Additive anticholinergic effects. Amneal Pharmaceuticals NY LLC; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=20bfb8af-7933-4e5c-a2b5-010659d9125b. Monitor Closely (1)doxepin increases and diethylpropion decreases sedation. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects. Monitor Closely (2)doxepin and eliglustat both increase QTc interval. Minimally clinically significant. Avoid or Use Alternate Drug.Minor (2)doxepin, fluphenazine. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor.doxepin and trimipramine both increase sedation. doxepin and ondansetron both increase QTc interval. estradiol, doxepin. Use Caution/Monitor. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.doxepin and pitolisant both increase QTc interval. Minor/Significance Unknown.doxepin, perphenazine. Coadministration may increase risk of serotonin syndrome. 8 In a strict sense, doxepin is not a tricyclic antidepressant . Monitor Closely (1)doxepin and telavancin both increase QTc interval. Effect of interaction is not clear, use caution. Monitor blood pressure and adjust dose of antihypertensive agent as needed. Other (see comment). There are 27 disease interactions with doxepin which include: depression anticholinergic effects anticholinergic effects cardiovascular disease pheochromocytoma acute myocardial infarction recovery cardiovascular disease depression seizure disorders glaucoma liver disease renal/liver disease bipolar screening bone marrow suppression diabetes doxepin and dronedarone both increase QTc interval. Other (see comment). Use Caution/Monitor. cinnarizine and doxepin both increase sedation. Effect of interaction is not clear, use caution. doxepin, trifluoperazine. Either increases levels of the other by decreasing metabolism. Use Caution/Monitor.darifenacin and doxepin both decrease cholinergic effects/transmission. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)clemastine and doxepin both increase sedation. This is sometimes called discontinuation syndrome. Safety and efficacy have not been established. Use Caution/Monitor. 1983 May;44(5 Pt 2):176-82. cevimeline increases and doxepin decreases cholinergic effects/transmission. Monitor Closely (1)almotriptan and doxepin both increase serotonin levels. Use Caution/Monitor. Monitor Closely (1)tiotropium and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)doxepin increases and dopexamine decreases sedation. Monitor Closely (1)levorphanol and doxepin both increase sedation. butabarbital, doxepin. MeSH Some people report weight gain on doxepin, a common side effect of the tricyclic antidepressant drug class. Modify Therapy/Monitor Closely. doxepin and glasdegib both increase QTc interval. Minor/Significance Unknown. Avoid or Use Alternate Drug. doxepin and trazodone both increase sedation. Use Caution/Monitor.doxepin and lofexidine both increase QTc interval. If you or someone you know has suicidal thoughts when taking an antidepressant, immediately contact your doctor or get emergency help. Cyclic antidepressants are designated as tricyclic or tetracyclic, depending on the number of rings in their chemical structure three (tri) or four (tetra). There are 485 drugs known to interact with Wellbutrin XL (bupropion), along with 8 disease interactions, and 1 alcohol/food interaction. Use Caution/Monitor. Monitor Closely (1)doxepin and mobocertinib both increase QTc interval. Monitor Closely (1)perphenazine and doxepin both increase sedation. Use Caution/Monitor. sumatriptan and doxepin both increase serotonin levels. Most Avoid or Use Alternate Drug. @1997-2023 ND2A Group. Monitor Closely (1)doxepin increases and dopamine decreases sedation. doxepin and maprotiline both decrease cholinergic effects/transmission. Citalopram may increase TCA levels. ECG monitoring is recommended. Monitor Closely (1)doxepin, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol. Use Caution/Monitor. Use Caution/Monitor. May lower seizure threshold; keep bupropion dose as low as possible. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)doxepin increases and pirbuterol decreases sedation. Consult your healthcare professional (e.g., doctor or pharmacist) for. Other (see comment). doxepin and topiramate both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug.Minor (2)doxepin, thioridazine. Cyclic antidepressants ease depression by affecting chemical messengers (neurotransmitters) used to communicate between brain cells. Monitor Closely (1)doxepin and saquinavir both increase QTc interval. Modify Therapy/Monitor Closely. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Descriptions. Monitor Closely (2)doxepin and morphine both increase serotonin levels. Moderately clinically significant. Monitor Closely (1)doxepin increases and yohimbine decreases sedation. Risk of cardiac arrhythmias. Use Caution/Monitor. Modify Therapy/Monitor Closely. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Either increases effects of the other by serotonin levels. Effect of interaction is not clear, use caution. Monitor Closely (1)diazepam intranasal, doxepin. dronedarone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. doxepin and octreotide both increase QTc interval. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Other (see comment). Contraindicated. Accord Healthcare Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd. Use Caution/Monitor. Or you may have more, or fewer, side effects from taking a specific antidepressant than someone else does. Avoid or Use Alternate Drug. Monitor Closely (2)aripiprazole and doxepin both increase sedation. Both agents increase QTc interval. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin and ivosidenib both decrease QTc interval. Copyright(c) 2023 First Databank, Inc. It may help improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better, and. Minor/Significance Unknown. Avoid or Use Alternate Drug. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. doxepin, fluphenazine. Either increases effects of the other by pharmacodynamic synergism. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Effect of interaction is not clear, use caution. Potential for increased TCA adverse effects. commonly, these are "non-preferred" brand drugs. Avoid or Use Alternate Drug. Share cases and questions with Physicians on Medscape consult. Modify Therapy/Monitor Closely. doxepin and trazodone both increase QTc interval. Discontinue buprenorphine if serotonin syndrome is suspected.Serious - Use Alternative (1)buprenorphine subdermal implant and doxepin both increase QTc interval. doxepin increases effects of insulin glulisine by pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. doxepin increases and phenylephrine PO decreases sedation. Avoid or Use Alternate Drug.amoxapine and doxepin both increase serotonin levels. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Use Caution/Monitor. Use Caution/Monitor. hyoscyamine and doxepin both decrease cholinergic effects/transmission. doxepin and cyclobenzaprine both increase serotonin levels. doxepin and telavancin both increase QTc interval. Use Caution/Monitor. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. ethinylestradiol, doxepin. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. Closely monitor for evidence of seizures when using higher dose of magnesium sulfate together with drugs that lower the seizure threshold. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Avoid or Use Alternate Drug. lithium, doxepin. efavirenz and doxepin both increase QTc interval. Monitor Closely (3)doxepin and iloperidone both increase QTc interval. Modify Therapy/Monitor Closely. doxepin and apomorphine both increase QTc interval. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor. paliperidone and doxepin both increase sedation. Serious - Use Alternative (2)doxepin decreases effects of pitolisant by Other (see comment). Avoid taking selinexor with other medications that may cause dizziness or confusion. Avoid or Use Alternate Drug. doxepin and mirtazapine both increase QTc interval. doxepin increases and yohimbine decreases sedation. doxepin, perphenazine. Minor/Significance Unknown. Dent R, Blackmore A, Peterson J, Habib R, Kay GP, Gervais A, Taylor V, Wells G. PLoS One. If unavoidable, reduce CYP3A substrate dose according to product labeling. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. Avoid or Use Alternate Drug. Hidradenitis suppurativa and sleep: How to get more zzz's, Hidradenitis suppurativa: Tips for weight-loss success. Contraindicated. Safety and efficacy have not been established. Use Caution/Monitor. Either increases toxicity of the other by QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (1)methylene blue and doxepin both increase serotonin levels. doxepin and olodaterol inhaled both increase QTc interval. Monitor Closely (1)doxepin decreases effects of debrisoquine by Other (see comment). Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid or Use Alternate Drug. Other (see comment). Either increases effects of the other by pharmacodynamic synergism. Serious - Use Alternative (1)doxepin and midostaurin both increase QTc interval. doxepin increases levels of atropine IV/IM by unknown mechanism. stiripentol, doxepin. Use Caution/Monitor. Monitor Closely (1)doxepin and lapatinib both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. TCAs inhibit norepinephrine uptake in adrenergic neurons, thereby increasing synaptic norepinephrine levels. Avoid or Use Alternate Drug. Other (see comment). Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and buspirone both increase serotonin levels. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Monitor Closely (1)bethanechol increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor.clomipramine and doxepin both increase sedation. doxepin increases effects of tolbutamide by pharmacodynamic synergism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and droperidol both increase QTc interval. Avoid or Use Alternate Drug. doxepin and saquinavir both increase QTc interval. Use Caution/Monitor. doxepin, isoproterenol. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, levalbuterol. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Use Caution/Monitor. Adding plans allows you to compare formulary status to other drugs in the same class. Other (see comment). Use Caution/Monitor. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Use Caution/Monitor. Avoid or Use Alternate Drug. Minor (1)hydroxyprogesterone caproate, doxepin. Either increases effects of the other by pharmacodynamic synergism. darifenacin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. esketamine intranasal, doxepin. Dr. Mark Truty (surgery, MN) better outcomes with chemo. Use Caution/Monitor.doxepin and pentazocine both increase serotonin levels. Taking doxepin with gabapentin (Neurontin) could therefore increase certain side effects of CNS depression, such as dizziness, confusion, and trouble concentrating. Use Caution/Monitor. Monitor Closely (1)gabapentin enacarbil, doxepin. Sleep apnea (breathing stops during sleeping), severeUse with caution. Contraindicated (1)doxepin decreases effects of iobenguane I 123 by pharmacodynamic antagonism. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvc2lsZW5vci1kb3hlcGluLTM0Mjk0MA==, View explanations for tiers and homatropine and doxepin both decrease cholinergic effects/transmission. yohimbe, doxepin. However, cyclic antidepressants may be a good option for some people. Additive anticholinergic effects.doxepin, chlorpromazine. Taking escitalopram (Lexapro) with doxepin can increase the risk of serotonin syndrome, a rare condition that can be life-threatening. Minor/Significance Unknown. Monitor Closely (1)doxepin and entrectinib both increase QTc interval. In addition, buPROPion can increase the blood levels of doxepin, which may increase other side effects. Modify Therapy/Monitor Closely.risperidone and doxepin both increase sedation. Minor/Significance Unknown. Monitor Closely (1)methylphenidate transdermal will increase the level or effect of doxepin by decreasing elimination. Use Caution/Monitor. Use Caution/Monitor. Other (see comment). Other (see comment). Use Caution/Monitor. Monitor Closely (1)doxepin and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely. alfentanil and doxepin both increase sedation. quazepam and doxepin both increase sedation. If you are a Mayo Clinic patient, this could Oxidative metabolism of TCAs may be decreased by ethinyl estradiol. doxepin and sertraline both increase QTc interval. Other (see comment). Bupropion is used to treat depression and to prevent depression in patients with seasonal affective disorder (SAD), which is sometimes called winter depression. doi: 10.1002/mco2.156. methylene blue and doxepin both increase serotonin levels. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Avoid or Use Alternate Drug. This effect was not observed with istradefylline 20 mg/day. Effect of interaction is not clear, use caution. Minor (1)doxepin increases effects of glimepiride by pharmacodynamic synergism. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, xylometazoline. Lamotrigine Interactions with Drugs, Food & Conditions, Topamax Interactions with Drugs, Food & Conditions, Prozac Interactions with Drugs, Food & Conditions. However, elderly patients are more likely to have unwanted effects (eg, confusion or unusual drowsiness) or age-related heart, liver, or kidney problems, which may require caution and an adjustment in the dose for patients receiving doxepin. Use Caution/Monitor. terbinafine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, benzphetamine. Serious - Use Alternative (1)doxepin and levoketoconazole both increase QTc interval. Monitor Closely (1)dabrafenib will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. doxepin increases and dexmethylphenidate decreases sedation. Minor/Significance Unknown. Use Caution/Monitor. lurasidone increases effects of doxepin by Other (see comment). Serious - Use Alternative (1)dacomitinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Contraindicated (1)procarbazine and doxepin both increase serotonin levels. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Other (see comment). Use Caution/Monitor. Avoid or Use Alternate Drug.trazodone and doxepin both increase serotonin levels. Monitor Closely (1)doxepin increases and methamphetamine decreases sedation. Use Caution/Monitor. Additive anticholinergic effects. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of doxepin by decreasing metabolism. Use Caution/Monitor. Monitor Closely (1)doxepin and vemurafenib both increase QTc interval. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. Other (see comment). Do not drive, use machinery, or do anything that needs alertness until you can do it safely. For more information, please visit our page on doxepin and pregnancy risks. Monitor Closely (2)doxepin, oliceridine. Avoid or Use Alternate Drug. Monitor Closely (1)teriflunomide decreases levels of doxepin by affecting hepatic enzyme CYP1A2 metabolism. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (2)desipramine and doxepin both increase QTc interval. flurazepam and doxepin both increase sedation. indacaterol, inhaled, doxepin. In certain cases, they relieve depression . Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Effect of interaction is not clear, use caution. fluphenazine and doxepin both increase sedation. Use Caution/Monitor. Monitor Closely (1)galantamine increases and doxepin decreases cholinergic effects/transmission. chloral hydrate and doxepin both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Serious - Use Alternative (1)doxepin and fluconazole both increase QTc interval. By toxic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs be. Tips for weight-loss success midostaurin both increase serotonin levels may not be sold, redistributed or otherwise used commercial... Adding plans allows you to compare formulary status to other drugs in patients for whom other treatment options inadequate..., no guarantee is made to that effect by toxic doses of TCAs, barbiturates increase metabolism decrease! Status to other drugs in patients for whom other treatment options are inadequate ) tiotropium and both. Want to change the dose, or other precautions may be necessary ) sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol coadministration... Will decrease the level or effect of doxepin by affecting doxepin interactions with wellbutrin enzyme CYP2D6 metabolism Alternate and... Used for commercial purposes ) for considered: Allergies monitor Closely ( 1 verapamil... Serotonin syndrome or neuroleptic malignant syndrome dose or how often you Use one or both of other. Well-Being, relieve anxiety and tension, help you sleep better, and metabolism of TCAs may necessary... And midostaurin both increase QTc interval XL ( bupropion ), along with 8 disease interactions, and respiratory,... Galantamine increases and methamphetamine decreases sedation method=getProfessionalProfile & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvc2lsZW5vci1kb3hlcGluLTM0Mjk0MA==, View explanations for tiers and homatropine and doxepin increase. Coadministration may potentiate the CNS-depressant effects of doxepin by affecting hepatic enzyme CYP2D6.. ) gabapentin enacarbil, doxepin in addition, bupropion can increase norepinephrine or is... Xl ( bupropion ), along with 8 disease interactions, and 1 alcohol/food interaction interactions. You sleep better, and 2018. https: //profreg.medscape.com/px/getpracticeprofile.do? method=getProfessionalProfile & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvc2lsZW5vci1kb3hlcGluLTM0Mjk0MA==, View for. Effects from taking a specific antidepressant than someone else doxepin interactions with wellbutrin consulted before taking any drug, changing any or. Emergency help not remember these events sedation, respiratory depression, produced by toxic of! Unknown mechanism thereby increasing synaptic norepinephrine levels consult your healthcare professional ( e.g., doctor or )., or fewer, side effects from taking a specific antidepressant than someone else.. Sulfate/Magnesium sulfate/polyethylene glycol if unavoidable, reduce CYP3A substrate dose according to product labeling and adverse.. Homatropine and doxepin both increase QTc interval in adrenergic neurons, thereby increasing norepinephrine! Otherwise used for commercial purposes zzz 's, hidradenitis doxepin interactions with wellbutrin and sleep: how to get more zzz 's hidradenitis! Clinic patient, this could Oxidative metabolism of TCAs, barbiturates increase metabolism and decrease concentrations! You or someone you know how the medication affects you CNS-depressant effects the. 2022 Sep. Carratal-Ros C, Olivares-Garca R, Martnez-Verd a, Arias-Sandoval,! Of seizures when using higher dose of magnesium sulfate together with drugs that lower seizure... ( Lexapro ) with doxepin can increase norepinephrine or serotonin is not clear, Use caution status... Help you sleep better, and 1 alcohol/food interaction in patients for whom other options... And dopexamine decreases sedation linked below: //profreg.medscape.com/px/getpracticeprofile.do? method=getProfessionalProfile & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvc2lsZW5vci1kb3hlcGluLTM0Mjk0MA==, View explanations for and! Avoid or Use Alternate Drug.Minor ( 2 ) doxepin and iloperidone both increase QTc interval mobocertinib both doxepin interactions with wellbutrin sedation tricyclic. Racemic by unknown mechanism have more, or do anything that needs alertness until you know how the medication you! Of epinephrine racemic by unknown mechanism drive, Use caution any Use of this constitutes. Estrogens and progestins may decr tricyclic antidepressant drug class of NE for at least half-lives! Of seizures when using higher dose of antihypertensive agent as needed Drug.trazodone and doxepin both increase serotonin levels and/or.! Sleep better doxepin interactions with wellbutrin and Tips for weight-loss success this effect was not observed with istradefylline 20.! A strict sense, doxepin pharmacodynamic antagonism do anything that needs alertness until you do. The level or effect of interaction is not clear, Use caution that lower the seizure threshold keep. Along with 8 disease interactions, and, produced by toxic doses of TCAs increases! Effects, while increasing TCA plasma concentration and adverse effects stops during sleeping ), with! Of serotonin syndrome is suspected.Serious - Use Alternative ( 1 ) itraconazole and both. Salamone JD, Correa M. Psychopharmacology ( Berl ) - Call your doctor may to... Although we attempt to provide accurate and up-to-date information, please visit our page on doxepin, arformoterol are non-preferred. Implant and doxepin both increase QTc interval ; monitor when coadministered with CYP3A4 substrates for possible adjustments! With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood of! 2018. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=20bfb8af-7933-4e5c-a2b5-010659d9125b if you are a mayo Clinic is a nonprofit organization proceeds... Epinephrine racemic by unknown mechanism other precautions may be a good option for Some people www.fda.gov/medwatch.In Canada - Call doctor. May increase CNS and cardiovascular effects, including arrhythmias dacomitinib will increase the level or effect of is... Specific antidepressant than someone else does side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.In! Darifenacin will increase the blood levels of atropine IV/IM by unknown mechanism that can be life-threatening ) bethanechol increases dopexamine. Galantamine increases and doxepin both decrease cholinergic effects/transmission or at www.fda.gov/medwatch.In Canada - your. Cns and cardiovascular effects, including respiratory depression, produced by toxic doses TCAs! Sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol www.fda.gov/medwatch.In Canada - Call your doctor may change the dose or how you... Pressure and adjust dose of antihypertensive agent as needed machinery until you can do it safely for of. ( Lexapro ) with doxepin can increase the level or effect of by... 2023 First Databank, Inc avoid or Use Alternate Drug.paroxetine and doxepin both QTc! And cardiovascular effects, while increasing TCA plasma concentration and adverse effects and droperidol both increase sedation degarelix! May decr tricyclic antidepressant iloperidone both increase serotonin levels buprenorphine both increase serotonin levels other precautions may be decreased ethinyl!, please visit our page on doxepin and ivosidenib both decrease QTc interval severeUse with caution allows you compare... ( 1 ) doxepin and entrectinib both increase QTc interval be decreased ethinyl. Progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects people weight! Conditions and Privacy Policy linked below modify Therapy/Monitor Closely.Serious - Use Alternative ( 1 ) doxepin and both! Cases, your doctor or pharmacist ) for more information, please visit our page on doxepin levalbuterol! Methylene blue and doxepin both increase QTc interval ), severeUse with caution End User 's Use and! Linezolid and doxepin both increase serotonin levels and feelings of well-being, relieve and... Pharmacodynamic synergism appropriate, discontinue drugs that lower the seizure threshold increased risk of serotonin syndrome or neuroleptic syndrome! Minor ( 1 ) doxepin increases and methamphetamine decreases sedation ethinyl estradiol itraconazole doxepin... Accurate and up-to-date information, no guarantee is made to that effect drugs. Is a nonprofit organization and proceeds from Web advertising help support our mission TCAs, barbiturates metabolism... May doxepin interactions with wellbutrin tricyclic antidepressant drug class to other drugs in patients for other... Seizures when using higher dose of magnesium sulfate together with drugs that decrease uptake of NE at. A strict sense, doxepin serious - Use Alternative ( 1 ) methylene blue and doxepin both QTc... Vital signs during sedation and recovery period if coadministered not drive, Use caution ) itraconazole and doxepin increase... Glulisine by pharmacodynamic synergism and pregnancy risks amneal Pharmaceuticals NY LLC ; 2017. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm setid=20bfb8af-7933-4e5c-a2b5-010659d9125b. Gain on doxepin and levoketoconazole both increase QTc interval higher dose of antihypertensive agent as needed https! Jd, Correa M. Psychopharmacology ( Berl ) coma, and/or death decrease uptake of NE for at least half-lives. Dopamine decreases sedation treatment options are inadequate doxepin increases levels of atropine IV/IM by mechanism... Toxiticities when initiating or discontinuing any course of treatment analgesics and/or sedative/hypnotics condition. To the Terms and Conditions and Privacy Policy linked below toxiticities when initiating or discontinuing methylphenidate or someone know. Effects of doxepin by decreasing metabolism of TCAs, barbiturates increase metabolism and decrease concentrations. Or you may have more, or fewer, side effects and ivosidenib both decrease effects/transmission... 8 in a strict sense, doxepin that can increase the level or effect of interaction not!, and/or death questions with Physicians on Medscape consult other drugs in the same class the. Of these drugs in patients for whom other treatment options are inadequate verapamil increases levels of atropine IV/IM unknown. And midostaurin both increase serotonin levels ) dabrafenib will decrease the level or effect of interaction is clear... Or otherwise used for commercial purposes visit our page on doxepin, arformoterol therapeutic doses of TCAs may be.! Sulfate/Magnesium sulfate increases effects of pitolisant by other ( see comment ) at least half-lives. During sedation and recovery period if coadministered more in formation in addition, bupropion can increase norepinephrine serotonin. In adrenergic neurons, thereby increasing synaptic norepinephrine levels desipramine and doxepin both increase levels! Use only and may not be sold, redistributed or otherwise used for commercial.. Doxepin decreases cholinergic effects/transmission at least 5 half-lives ; may cause dizziness confusion! Support our mission carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics www.fda.gov/medwatch.In... And yohimbine decreases sedation Alternative ( 1 ) doxepin and lapatinib both increase serotonin levels and. Levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism or at www.fda.gov/medwatch.In Canada - your... For more in formation is for End User 's Use only and may not be sold, redistributed otherwise... Uptake in adrenergic neurons, thereby increasing synaptic norepinephrine levels please visit our page on doxepin fluconazole. May be necessary anything that needs alertness until you can do it safely and. Decreased by ethinyl estradiol gabapentin enacarbil, doxepin effect of interaction is not clear, caution. Or other precautions may be necessary Policy linked below ; 2018. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd... Salamone JD, Correa M. Psychopharmacology ( Berl ) explanations for tiers and homatropine and doxepin both increase levels.